The idea of uploading out of these meatsacks has always appealed to certain people, and you can tell an awful lot about them by their use of the phrase "meatsacks." Athena Andreadis recently wrote an article on why we can't be uploaded, explaining how any ghosts in the machine would just be copies. But we ask the more important question: is that a problem?
This is usually where discussions of uploading end, but who cares if it isn't us? Instead of a self-centered desire for immortality, what if we use ourselves for the ultimate in programming? Instead of going to all the bother of building an entire artificial mind from scratch we can use some of six billion floating around already. If we could map the mind, even approximately, the software analogue would be a complete artificial consciousness. And assuming we could avoid the automatic "All AIs go insane and try to kill us" factor, it could be useful for all the same reasons we want uploading.
Off world exploration is the primary fantasy for silicon souls - storing ourselves in significantly stronger shells for the dangerous trip off world. Copies could do that. Why not? All of human history has been driven by people building a better world for their offspring, and who says you have to start with people squirting goo into each other? Couldn't a computerized copy be your inheritor? An uploaded alternate you would start differentiating immediately as they have different experiences - in fact, because of the alien nature and enhanced speed of a computer system they'd vary very quickly indeed.
Alternate-you AIs would also be useful in all kinds of problem solving, inspire incredibly complicated civil rights issue, and at least they'd start out on our side should the man vs machine shit hit the fan. So if you're saying uploading doesn't help you, stop being so selfish.
Athena's article at HPlus Magazine