What these scientists have done could give us the first
bulletproof HIV vaccine. They have re-awakened the human genome's
latent potential to make us all into HIV-resistant creatures; they published their ground-breaking research in PLoS Biology.
group of scientists led by Nitya Venkataraman and Alexander Colewhether
wanted to try a new approach to fighting HIV - one that worked with the
body's own immune system. They knew Old World monkeys had a built-in
immunity to HIV: a protein called retrocyclin, which can prevent HIV
from entering cell walls and starting an infection. So they began
poring over the human genome, looking to see if humans had a latent
gene that could manufacture retrocyclin too. It turned out that we did,
but a "nonsense mutation" in the gene had turned it off at some point
in our evolutionary history.
Nonsense mutations are caused when
random DNA code shows up in the middle of a gene, preventing it from
beginning the process of manufacturing proteins in the cell.
Venkataraman and her team decided to investigate this gene further,
doing a series of tests to see if the retrocyclin it produced would
keep HIV out of human cells. It did.
At last, they knew that if
they could just figure out a way to reawaken the "junk" gene that
creates retrocyclin in humans, they might be able to stop HIV
infections. The researchers just needed to figure out a way to remove
that nonsense mutation and get the target gene to start manufacturing
Here's where things really get interesting.
The team found a way to use a compound called aminoglycosides, which
itself can cause errors when RNA transcribes information from DNA to
make proteins. But this time, the aminoglycoside error would work in
their favor: It would cause that RNA to ignore the nonsense mutation in
the junk gene, and therefore start making retrocyclin again. In
preliminary tests, their scheme worked. The human cells made
retrocyclin, fended off HIV, and effectively became AIDS-resistant. And
it was done entirely using the latent potential in the so-called junk
DNA of the human genome.
After more research is done, the researchers believe this might become a viable way to make humans immune to HIV infection.
especially intriguing, beyond the amazing idea of an AIDS vaccine, is
that aminoglycosides have the potential to unlock the uses for other
pieces of junk DNA. In Darwin's Radio, certain portions of these "non-sense" sequences, remnants of prehistoric retroviruses, have been activated by aminoglycosides
the novel, humans start rapidly evolving after their junk DNA
re-awakens in response to stress. Could we induce instant mutations, or
gain other new immunities by using aminoglycosides on our junk DNA?
via PLoS Biology
Posted by Casey Kazan.
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