Darwin's Radio: Prehistoric Gene Reawakens to Battle HIV
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April 29, 2009

Darwin's Radio: Prehistoric Gene Reawakens to Battle HIV

Darwinsradio_full 'The next great war will start inside us. 'In the next stage of evolution, mankind is history'.

Greg Bear, Darwin's Radio

About 95% of the human genome has once been designated as "junk" DNA. While much of this sequence may be an evolutionary artifact that serves no present-day purpose, some junk DNA may function in ways that are not currently understood. The conservation of some junk DNA over many millions of years of evolution may imply an essential function that has been "turned off." Now scientists say there's a junk gene that fights HIV. And they've discovered how to turn it back on.


What these scientists have done could give us the first bulletproof HIV vaccine. They have re-awakened the human genome's latent potential to make us all into HIV-resistant creatures, and hey've published their ground-breaking research  in PLoS Biology.

A group of scientists led by Nitya Venkataraman and Alexander Colewhether wanted to try a new approach to fighting HIV - one that worked with the body's own immune system. They knew Old World monkeys had a built-in immunity to HIV: a protein called retrocyclin, which can prevent HIV from entering cell walls and starting an infection. So they began poring over the human genome, looking to see if humans had a latent gene that could manufacture retrocyclin too. It turned out that we did, but a "nonsense mutation" in the gene had turned it off at some point in our evolutionary history.

Nonsense mutations are caused when random DNA code shows up in the middle of a gene, preventing it from beginning the process of manufacturing proteins in the cell. Venkataraman and her team decided to investigate this gene further, doing a series of tests to see if the retrocyclin it produced would keep HIV out of human cells. It did.

At last, they knew that if they could just figure out a way to reawaken the "junk" gene that creates retrocyclin in humans, they might be able to stop HIV infections. The researchers just needed to figure out a way to remove that nonsense mutation and get the target gene to start manufacturing retrocyclin again.

Here's where things really get interesting. The team found a way to use a compound called aminoglycosides, which itself can cause errors when RNA transcribes information from DNA to make proteins. But this time, the aminoglycoside error would work in their favor: It would cause that RNA to ignore the nonsense mutation in the junk gene, and therefore start making retrocyclin again. In preliminary tests, their scheme worked. The human cells made retrocyclin, fended off HIV, and effectively became AIDS-resistant. And it was done entirely using the latent potential in the so-called junk DNA of the human genome.

After more research is done, the researchers believe this might become a viable way to make humans immune to HIV infection.

What's especially intriguing, beyond the amazing idea of an AIDS vaccine, is that aminoglycosides have the potential to unlock the uses for other pieces of junk DNA.  In Darwin's Radio, certain portions of these "non-sense" sequences, remnants of prehistoric retroviruses, have been activated by aminoglycosides
In the novel, humans start rapidly evolving after their junk DNA re-awakens in response to stress. Could we induce instant mutations, or gain other new immunities by using aminoglycosides on our junk DNA?

via PLoS Biology

Posted by Casey Kazan.

Related Galaxy posts:

Did Ancient Viruses Spur Human Evolution? A Galaxy Insight
"Voyage of the Beagle 2" -The Search for Microbial DNA
“Playing God” -Scientists in Final Stage of Creating Man-made Life
Darwin's Lab: Scientists on Brink of Creating Life

Comments

Have we now entered the realm of the Creator? Is it possible we are but a fragment of life from an older, designed species from a time gone by? Are the Creationists strong suspicions founded in some elementary understanding of the Universe, as yet unrevealed by Science and its persistent probing for truth? Quo vades, little monkey, and where did you come from? and why?

I think that the description of a nonsense mutation is a little vague and inaccurate, nonsense mutations result from a number of sequence aberrations such as indel mutations (base pair insertions or deletions)or transition/trasversion mutations between base pairs (ie. purine/pyrimidine exchanges like A -> C). The nonsense mutation should not be described as "random code showing up in the middle of a gene" but the product of one of the above mutations ending in a truncated (non-functional protein). In addition I am curious as to the mechanism by which aminoglycosides incurs transcription errors and since it does, what possible control mechanism can be employed to prevent it from affecting other genes as this agent interferes with transcription. What is to prevent it from botching the transcription other coding sequences and causing missense or nonsense mutations and compromising other gene products.

--William

What is the link to the actual article?

Nice article! Human biology continues to amaze me.

To McGee and others:
I think this is based on this article
http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.1000093

(stuff like this really needs proper references(!) and not just via's)

"They knew Old World monkeys had a built-in immunity to HIV: a protein called retrocyclin, which can prevent HIV from entering cell walls and starting an infection."

I was under the impression that animals do not have cell walls but rather they have cell membranes instead.

Great article otherwise.

This is the original article:

http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.1000095

Perhaps all the viruses around today, HIV included, have been in circulation for much longer than we think, having been both active within species and not, many times over the ages. It stands to reason, if that is possible, then perhaps for all our illnesses there is already a cure within our own DNA that just needs to be activated and that natural immunities to diseases are in fact mutations that happen to activate that age-old immunity in a few people. As those genes weren't required any more, it was sectioned off into areas of junk DNA as the virus died out.

Sci-fi... probably, but it's fun to think about.

Author: Humans don't have cell walls. You learned that in the fourth grade.

Point 1:
HIV has already found a way to evade the inhibitory effects of Retrocyclin. Granted it makes the virus much less efficient at entering into the cell, but it can still infect. The idea that the spread of HIV infection (and subsequently AIDS) can be prevented is naive, stupid and wasteful. The time and money needs to be spent on life-style management and therapy solutions.

Point 2:
It is absolutely inaccurate to call a DNA stretch that can produce any kind of product (such as protein, peptide...) Junk DNA. The whole point of the term Junk was that they assumed it did not have a function. But now they know that the so called Junk DNA or Introns actually have a huge role in regulating gene expression. So even if they don't code for any product they still have a use and function (a lot of which are unknown).

Come on Sara, no immunisation is 100% effective, if this therapy can reduce the infection rate by any percentage it's worth pursuing. I find it amusing that you equate research with naivety and waste, and then promote "life-style management... solutions". Combating disease is always a two-pronged approach, you need both behavioural and technological controls for best results.


THE CURE for HIV/AIDS.......AMBUSH

THE IDEA that AMBUSH cures AIDS
is being proven by the more than 400 individuals who have taken a dose of 60 ml three times daily for 21 days. The result is that AMBUSH 'KILLS' the virus by causing the protein envelope to rupture and the viral particles are discarded by the white blood cells. AMBUSH is able to 'KILL' the virus that are 'hiding' in the lymph system by its 'natural radioactive' properties. This process allows the body to 'return to normal health' with a corresponding immunity to that or those strains of the virus.

What is AMBUSH ?
AMBUSH is a radioactive isotope of uranium that is found in the 'palm' plant of which there are more than 3000 species. When ingested, AMBUSH causes the body temperature in the trunk area to rise to about 102 degrees when the individual is sleeping. The preparation takes four hours per batch, which is then given to the individuals for consumption 60 ml three times daily for 21 days. AMBUSH is a herbal preparation in this form but it contains an active ingredient which is a 'NEW' crystalline substance, a drug from the 'palm plant' similarly to ASPIRIN originating from the willow tree bark

RESULTS:
After 21 days on AMBUSH, ALL the individuals experienced a decrease in viral load to undetectable, an increase in cd4, increase in RBC, an improvement in general health such as more color to the face, decrease in Buffalo hump, an increase in gluteal muscles, a decrease to having no joint pains whereby individuals can bend to touch their toes, and walk up steps are but a few examples. There is also a dramatic increase in their sexual appetite beginning after the first week of therapy

DISCUSSION:
In any plant concoction such as percolated 'tea', there are 30-40,000 compounds, whi ch would take the scientific community twenty years to isolate one particular ingredient if they knew what they were looking for. The LORD GOD has given me seven steps to isolate the active ingredient, which is soft and metallic in nature and has a carbon- uranium-sulfur-(classified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure.

As an antiviral and 'natural radioactivity' producing agent, AMBUSH is also effective against leukemia, lupus and HPV. Here I am saying that I have 'GIVEN' AMBUSH in the same 'strength' and dosage to patients with leukemia, lupus and HPV. A 35 year old male with HIV found it difficult to impossible to urinate was put on 'green tea' and water while the doctors contemplated prostrate surgery. One of the doctors gave him my number , I sent him a supply of AMBUSH an d he has not been given any more ARV's, since taking AMBUSH 18 months ago, is in 'good' health and has expressed a willingness to be examined by HIV investigators like many others who have taken AMBUSH.

I have sent this 'IDEA' to most HIV research agencies, scientist of the field, universities, hospitals, clinics, politicians and news agencies to which it is REJECTED because the name of THE LORD GOD is mentioned. He has steered me scientifically through the processes such as which plant and how to produce the active ingredient. What are the odds of a Florida Pharmacist picking a plant would contain the CURE for HIV/AIDS ?
I have never charged any of the people for their supply of AMBUSH but a life saving has been spent on the project with NO renumeration from any sources because AMBUSH falls outside the walls of modern medicine and research.

PROPOSAL:

My proposal is that I PROVE that AMBUSH CURES HIV/AIDS by giving it to a number of END-STAGE or DRUG-RESISTANT people and the scientific community watches their recovery. This proposal addresses the problem in that I have already outlaid the results to be obtained.

This IDEA is unconventional in that the scientific community has rejected AMBUSH because I say it is GOD given. Secondly if I wrote it according to certain standards, then it might be peer reviewed. However, THE LORD GOD has also shown me that there are five enzyme systems associated with the virus, reverse transcriptase, protease, fusion and two more of which causes the virus to be AIRBOURNE. This means that without DIVINE intervention mankind and ALL warm- blooded mammals will be extinct in a number of years.

The PROOF of what I am saying is found in scientific papers wherein it is found that when the protease cuts the viral strands, it cuts it at DIFFERENT lengths EVERY time, to which it should always be a valine at the end but is a different amino acid every time. This is why it is IMPOSSIBLE to produce a VACCINE.

Since this is NOT a hypothesis but there are about 400 individuals who have taken AMBUSH, here lies a vast area in which to check, recheck and confirm that AMBUSH CURES AIDS. Let it be mentioned that during the HIV reproductive cycle, reverse transcriptase converts viral RNA into DNA compatible to human genetic materials. Thus the human DNA has been 'hijacked' and since each person has a DIFFERENT DNA, then the new viral copy is unique to that person which shows that each individual has a DIFFERENT STRAIN of the virus. Consider two HIV positive people swapping viral strains and increasing its complexity with multiple partners.
It can also be proposed that they be revisited as proof that the strain or strains that they had were 'killed' at the time of taking AMBUSH considering that a person can catch as many different strains as there are people who are infected by HIV.
I am also willing to work with the scientific community in identifying those individuals who took AMBUSH and wish to be identified with this process notwithstanding that some are stigmatized while others are jubilant,

Once AMBUSH is verified as being able to accomplish that which is aforementioned then the next stage might be the natural and artificial synthesis of the substance.

Finally, if this is accepted or not, believed or not, THE LORD GOD always wins and this is the heavenly truth to which AMBUSH was divinely given to mankind for the CURE of HIV/AIDS and it will be here forever. Apostle Shada Mishe.

apostleshadamishe@gmail.com

Here is a video taped presentation that I gave at t he Martin Luther King library in Washington

http://www.youtube.com/watch?v=8V53D1w__Po
http://www.youtube.com/watch?v=vPwuwlVBOV0
http://www.youtube.com/watch?v=ZejptOwMTzQ
http://www.youtube.com/watch?v=CqcTgIAhrhc
http://www.youtube.com/watch?v=f7HPKcT_iwY
http://www.youtube.com/watch?v=W9iQfgiYAnw
http://www.youtube.com/watch?v=i3RzRS6tJDM


Apostle Shada Mishe, your ideas are intriguing to me and I wish to subscribe to your newsletter.

OK--this is all interesting except for one thing--it is all BS
please google "HIV is a myth"

there is really no evidence that HIV is real or that it causes AIDS

seriously, how can you write an article and not even research the most basic premise??

:lol at Dawn. Yeah right. HIV don't exist. This is the 2009 dear, the HIV virus has been shown to exist, and to cause AIDS. SO STFU and stop living in Duesberg's world.

hmm, im quite sure i read it somewhere that direct ascendants of the survivors of europs black plague are immune to hiv. and that was like 2 years ago.

maybe i dreamed it up.

now listen i just want to interject some insight to this and most matters of wonder. galaxy is the key word here. uderstand this. if god is in question ezeikel stood in a field of bones and god formed new flesh. is god a sick lier or is gods anger still white hot. people would live over 600 years at one time. (bable)still love is the key to all endevers. now earth. evelution. and money. the weather. and life. will life continue to repeat mistakes. no. alone in the galaxy . yes.can you see not to be what you think is division. be what you are for the trueths sake. HOLLAND CHURCH

Posted for boneymaloney:

It has been more than 20 years that they have discovered HIV and have been trying to mitigate its replication, virulency and potency and no avail. There is no promising research of any kind that has hinted to being able to cure or prevent HIV infection once a person has contracted it. It will never be, at least with the current data. I am a biochemist and I do research for school and for a living. I work with HIV. It is unrealistic to pour money into a category that is literally and figuratively a waste of time. They need better drugs, combination of drugs, cheaper drugs, better STD prevention advocacy, global effort in making the life of these people easier, safer and healthier. Not to chase after a concept, while noble, is absolutely irrelevant in the context of lives lost.
The virus can adapt so well that an individual can have several strain made within him/her in a given period of time. This can happen due to its powerful mutation capabilities. They have also discovered that it might be able to sequester itself so the body won't detect it for years. It can also turn the body against itself to kill any defensive cells; this is in the years that it takes to develop AIDS (roughly between the first 5-15 years). They cannot even make drugs to slow it down that can be effective continuously.
Their efforts are focused on an ideology which takes away from the reality of lives dealing with the disease.

By the way I don't equate research on HIV with naiveté and wastefulness. I equate the attention, money, glory, sensationalized publicity... that the so called HIV "cure" gets with a waste of time. That is what irks me. That is what pains me and depresses me. If I were trying to get grant for HIV that did not involved some sort of vaccine/drug/cure development, I would not be even considered for it.

It has been more than 20 years that they have discovered HIV and have been trying to mitigate its replication, virulency and potency and no avail. There is no promising research of any kind that has hinted to being able to cure or prevent HIV infection once a person has contracted it. It will never be, at least with the current data. I am a biochemist and I do research for school and for a living. I work with HIV. It is unrealistic to pour money into a category that is literally and figuratively a waste of time. They need better drugs, combination of drugs, cheaper drugs, better STD prevention advocacy, global effort in making the life of these people easier, safer and healthier. Not to chase after a concept, while noble, is absolutely irrelevant in the context of lives lost.
The virus can adapt so well that an individual can have several strain made within him/her in a given period of time. This can happen due to its powerful mutation capabilities. They have also discovered that it might be able to sequester itself so the body won't detect it for years. It can also turn the body against itself to kill any defensive cells; this is in the years that it takes to develop AIDS (roughly between the first 5-15 years). They cannot even make drugs to slow it down that can be effective continuously.
Their efforts are focused on an ideology which takes away from the reality of lives dealing with the disease.

Wait…WHAT?
HIV doesn’t exist? HAHA…are you shitting me? Seriously?
Sorry to be rude, but…actually I am not sorry to be rude…are you fucking retarded? Its people like you that read junk and believe it. If you can’t even formulate a sane argument please don’t.

You just leave yourself wide open for ridicule…
LIKE THIS ONE!!!


Dawn, no need to reply to my post. I really have no interest reading what you have to say at all.

For Shada Mishe :

One problem kid…


HIV integrates into the cell DNA. So it doesn’t matter that the envelope ruptures. Whenever the cell replicates naturally it will make the virus all over again. And the envelope will assemble. So it might prevent its progression to a certain degree but after a while it will stop working (like EVERY other drug they have made so far).


THERE IS NO CURE FOR HIV.

If molecular genetics/virology/biochemistry/microbiology was so straightforward and simple then we would have accomplished so much more a long time ago.


Good Xenu…people are such trivializing animals.

Here is the article that renders Retrocyclin useless:

http://cat.inist.fr/?aModele=afficheN&cpsidt=17796210

Awesome Picture!!!

What kind of camera?

acai

I say activate them all...

incredible hulk?
superman?
mclovin?

I think HIV is a form of population control and should be left alone.


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