Genomes Show "Evolutionary Arms Race" Over Millions of Years

By comparing the genomes of humans and five other mammals, Cornell researchers have identified 544 genes that have been shaped by positive selection over millions of years of evolution in one of the largest and most comprehensive analysis of positive selection ever undertaken.

In earlier studies, the Cornell group compared the genomes of humans, chimpanzees and the Rhesus macaque. By extending the analysis to mice, rats and dogs, the researchers were able to find "stronger signals" of change by going back up to 80 million years on the evolutionary tree.

The researchers used a high-performance computer cluster at the Cornell Center for Advanced Computing to study 16,500 human genes that are also found, with some differences, in at least two of the other five species.

Many of the positively selected genes found in rodents involved immunity and defense, including defense against bacteria and viruses, suggesting an evolutionary "arms race" with pathogens. Responses to wounding and inflammation were also common.

Over time, random changes can occur in the genetic code that replace one of the amino acids in a protein with another. Sometimes these changes have no effect on the function of the protein. But if the change alters the function of the protein and the change is beneficial -- if, for example, it protects against a disease that is common in a certain time and place -- individuals with the new version of the gene will be more likely to survive than others, and the new version will gradually replace the old one in an evolving population.

The group used the unimportant changes as a sort of clock to show how much change would be expected over evolutionary time. If a gene showed significantly more change than expected by random chance it was predicted to be under positive selection.

The largest group of positively selected genes in primates involved perceptions of taste, color and pain. "The conventional wisdom is that we should see major changes in the brain-related genes," team leader Adam Siepel noted. "We didn't find a signal for that, but did find inputs to the central nervous system." Perhaps changes in sensory input drove changes in the brain.

The study supports the idea that positive selection is important in evolution. Theorists have argued over the relative importance of positive selection versus "neutral drift," where random changes simply happen with no positive or negative result.

The researchers also found evidence that many changes seem to have occurred in spurts over short periods of time. For example, they found genes that were not under selection in lower mammals, then came under selection in primates, then were lost in humans. Whether evolution has been continuous or periodic has also been a subject of much debate among biologists.

Posted by Jason McManus.

Source: http://www.physorg.com/news140797545.html

Comments

[Brian H]

The "silent DNA" seems to contain selective mutation control functions that would operate like learned rules for beneficial positive selection. They would be immensely powerful and beneficial, and thus themselves subject to strong positive selection. Which implies another layer of "rules" for managing them, too. Very much like the way neural nets operate.